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Abstract Lanthanides, which are part of the rare earth elements group have numerous applications in electronics, medicine and energy storage. However, our ability to extract them is not meeting the rapidly increasing demand. The discovery of the bacterial periplasmic lanthanide‐binding protein lanmodulin spurred significant interest in developing biotechnological routes for lanthanide detection and extraction. Here we report the construction of β‐lactamase‐lanmodulin chimeras that function as lanthanide‐controlled enzymatic switches. Optimized switches demonstrated dynamic ranges approaching 3000‐fold and could accurately quantify lanthanide ions in simple colorimetric or electrochemical assays.E.colicells expressing such chimeras grow on β‐lactam antibiotics only in the presence of lanthanide ions. The developed lanthanide‐controlled protein switches represent a novel platform for engineering metal‐binding proteins for biosensing and microbial engineering. 

We consider the problem of optimal control of district cooling energy plants (DCEPs) consisting of multiple chillers, a cooling tower, and a thermal energy storage (TES), in the presence of time-varying electricity price. A straightforward application of model predictive control (MPC) requires solving a challenging mixed-integer nonlinear program (MINLP) because of the on/off of chillers and the complexity of the DCEP model. Reinforcement learning (RL) is an attractive alternative since its real-time control computation is much simpler. But designing an RL controller is challenging due to myriad design choices and computationally intensive training. In this paper, we propose an RL controller and an MPC controller for minimizing the electricity cost of a DCEP and compare them via simulations. The two controllers are designed to be comparable in terms of objective and information requirements. The RL controller uses a novel Q-learning algorithm that is based on least-squares policy iteration. We describe the design choices for the RL controller, including the choice of state space and basis functions, that are found to be effective. The proposed MPC controller does not need a mixed integer solver for implementation, but only a nonlinear program (NLP) solver. A rule-based baseline controller is also proposed to aid in comparison. Simulation results show that the proposed RL and MPC controllers achieve similar savings over the baseline controller, about 17%. 

We present an open-source wireless network and data management system for collecting and storing indoor environmental measurements and perceived comfort via participatory sensing in commercial buildings. The system, called a personal comfort and indoor environment measurement (PCIEM) platform, consists of several devices placed in office occupants’ work areas, a wireless network, and a remote database to store the data. Each device, called a PCFN (personal comfort feedback node), contains a touchscreen through which the occupant can provide feedback on their perceived comfort on-demand, and several sensors to collect environmental data. The platform is designed to be part of an indoor climate control system that can enable personalized comfort control in real-time. We describe the design, prototyping, and initial deployment of a small number of PCFNs in a commercial building. We also provide lessons learned from these steps. Application of the data collected from the PCFNs for modeling and real-time control will be reported in future work. We use hardware components that are commercial and off-the-shelf, and our software design is based on open-source tools that are freely and publicly available to enable repeatability. 

Abstract This paper presents a novel architecture for model predictive control (MPC)-based indoor climate control of multi-zone buildings to provide energy efficiency. Unlike prior works, we do not assume the availability of a high-resolution multi-zone building model, which is challenging to obtain. Instead, the architecture uses a low-resolution model of the building that is divided into a small number of “meta-zones” that can be easily identified using existing data-driven modeling techniques. The proposed architecture is hierarchical. At the higher level, an MPC controller uses the low-resolution model to make decisions for the air handling unit (AHU) and the meta-zones. Since the meta-zones are fictitious, a lower level controller converts the high-level MPC decisions into commands for the individual zones by solving a projection problem that strikes a trade-off between two potentially conflicting goals: the AHU-level decisions made by the MPC are respected while the climate of the individual zones is maintained within the comfort bounds. The performance of the proposed controller is assessed via simulations in a high-fidelity simulation testbed and compared to that of a rule-based controller that is used in practice. Simulations in multiple weather conditions show the effectiveness of the proposed controller in terms of energy savings, climate control, and computational tractability.